Modifier XU

Distinct-service X{EPSU} (replace 59 when one applies)

Modifier XU. Unusual Non-Overlapping Service — distinct because it does not overlap the main service's usual components.

This is a high-denial-risk modifier and a known OIG audit target — append it only when the documentation supports a distinct or separately identifiable service.

Reference only — CPT descriptors are AMA-copyrighted (paraphrased). Payment percentages and acceptance vary by payer; verify against the current CPT/HCPCS files and payer policy.

Related modifiers

Separate Encounter — distinct because it occurred during a separate encounter, s…

Separate Structure — distinct because performed on a separate organ/structure.

Separate Practitioner — distinct because performed by a different practitioner.

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